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What Are Thre Symptoms Of Severe Migraines?

Migraines can be severe headaches that are often accompanied with nausea, sensitivity and light. An aura is a sensory disturbance that is perceived as causing a disturbance in the brain, such as a strange light or unpleasant smell.


By a margin of 3-1, migraines are more common in women than in men. Why is this such a big difference? Recent research using a mouse model is helping to answer this question. Researchers at UCLA Department of Neurology used mice years ago to study a phenomenon known as cortical spreading depression (CSD), that has been suspected to be a major cause of migraines.

They found a significant difference in the triggering of CSD between males and women during their experiments. In the past, migraines were believed to be caused by constriction and dilation in blood vessels. However, brain excitability has been shown to be a more likely cause.

Let’s understand it

Cortical spreading depression was found in migraine patients using a variety modern neuro-imaging techniques. CSD, as it’s commonly called, is a series of distinct waves of activity that spread across a brain’s surface. These waves are suspected to cause migraine pain and trigger nausea, sensitivity and auras. According to Dr. Charles of UCLA, the strength of the stimulus needed to trigger CSD in males was two to three times greater than that required to trigger the response for females.

This means that migraines are more common in women than in men. Although Dr. Charles did not give any explanations for this “intrinsic exitability,” it does indicate that women are more likely to get migraines due to it. There were also factors that could lower the CSD threshold in males than females, making them more likely to get migraines.


These factors included diet, stress levels, sleeping patterns and environmental triggers. The study found no difference in threshold levels between males and women. Dr. Charles and his colleagues are optimistic about the results, but acknowledge the need to do more studies to confirm them. Their findings may help to understand the mechanism behind the rise in migraine headaches among women, they believe.