Ilustración médica en 3D de una célula cancerosa en división con una superficie celular

¿Cuál es la relación entre las células inmunitarias y la regeneración de las lesiones musculares?

A recent study by the Stanford study team has concluded that the deliver signal to trigger stem cell regeneration. Immune cells trigger cells for muscle regeneration and repair which will assist in treating muscle ailments. Studies indicate that a gene Adamts 1 has switched on in those cells. This is a key which activates satellite cells in the event of muscle injury. But the Adamts 1 does not seem to make the protein in the injury.


There’s a white cell called macrophage (literally signifies eaters) that is accountable for producing the protein in the injury site. They travel to the and keep it clean and healthy by , the dead cells and viruses. They also release protein to alert the to fight the . While cleaning the wound it also signals the muscle to regenerate. The Adamts 1 also nips a protein called NOTCH that’s found on the satellite surface. NOTCH suggests to the satellite mobile to remain dormant.

When Adamts 1 destroys NOTCH, the satellite mobile becomes activated, and begins to divide and change into muscle cells. There’s a direct link between the cells which wash the injury and they also indicate it to begin regenerating and rebuilding the muscle which was destroyed. This aspect is present only in the uninjured muscles. Macrophages release Adamts 1 that nips the protein of this NOTCH that keeps them at a restful stage.


When NOTCH is deactivated the cells begin making new muscle. Mice which were examined with this Adamts 1 have demonstrated a curious case. It’s seen that they have more muscle damage and the muscle stem cells decrease over and Adamts 1 becomes less effective at fixing the damaged muscle. More importantly it’s just 1 cell that’s able signal to the muscle stem cells and excite to distinguish muscle. These cells are also known as muscle stem cells. These lay dormant and only come into action if there’s an injury and harm from it. The satellite cell function breaks down because of aging and diseases like muscular dystrophy.

These satellite cells dramatically reduce in and cannot divide any longer which results in muscle degeneration. The study also says that this plays an significant role in its activation. The gives a deep comprehension of muscle regeneration, and fix which will aid in the development of new treatments for various muscle ailments.


Previous studies on a gene named Adamts 1 suggest it is turned on strongly from the activated satellite cells compared to the cells that were dormant. Most important is how a single protein is sufficient to send a signal to the muscle stem cells and stimulate them and they are able to differentiate muscles. This makes it a natural mechanism that may be exploited to help support the efforts of building and healing therapies to enhance drastically.