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Warum sprechen Sie nicht auf Depressionsmedikamente an?

Maria has been feeling depressed for at the very least two . 5 years. Around three years back, her husband of twenty years left her for an other woman. Devastated, she became despondent and tearful daily almost. Eventually, her depression got worse connected with inability to operate. Her appetite, energy, concentration, and sleep became impaired.

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She felt hopeless and suicidal also. Her psychiatrist put her on a starting dose of antidepressant. She responded but following a couple of days initially, she felt like before taking the medication just. For days gone by 2 yrs, Maria has tried four forms of antidepressants. She’s taken the most common adult doses of the drugs. Although she improves somewhat, she’s remained exactly the same — depressed and disabled virtually. Maria appears to regularly be taking the medications. But how come she not giving an answer to her antidepressants? Maria is merely one of the numerous depressed individuals who don’t feel “normal” despite treatment.

Depression is really a treatable disease but why some individuals don’t prosper on medications? There are plenty of explanations why depressed patients like Maria don’t improve on antidepressants. First, may be the diagnosis correct? Depression could be due to many clinical entities. Sometimes, knowing the proper diagnosis is really a challenge. Medical disorders, medications such as for example beta-blockers and benzodiazepines (e.g. clonazepam), and different psychiatric disorders could cause depression plus they all require different treatment. If your physician does not identify and treat the real reason behind your depression, you shall remain depressed regardless of the usage of antidepressant.

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Second, is there co-morbid disorders? Depression can exist and also other psychiatric disorders such as for example anxiety disorder, drug or alcohol problems, personality disorder, dementia, and psychosis. Depression shall persist if these co-morbid disorders aren’t treated. For instance, depressive disorder with psychosis can’t be adequately alone treated just with antidepressant. You will need an antipsychotic drug put into an antidepressant to take care of the condition. Third, can be an ongoing neurological or medical disorder that precipitates there, aggravates, or complicates depression? Hypothyroidism, hyperthyroidism, vitamin B-12 deficiency, pancreatic cancer, brain tumor, Parkinson’s disease, and stroke can all cause depression.

If these disorders can be found, antidepressants are less inclined to help. The target in these circumstances would be to treat the underlying condition. A 65 year-old lady found see me complaining of severe depression. On evaluation, she disclosed that she have been on three forms of antidepressants for days gone by four years with reduced response. She was checked by me recent laboratory results which showed an abnormal thyroid! No wonder, she had not been giving an answer to the medication.

Fourth, is there ongoing psychosocial issues? Financial problems, family conflict, work-related stress can precipitate and complicate depression. Despite adequate medication treatment, a lot of people will stay depressed particularly if such problems aren’t addressed by the psychiatrist or therapist. Will there be any real way it is possible to decrease the stressors? Please achieve this the earliest it is possible to.


The treating depression straightforward is generally. However occasionally, various factors complicate it. For antidepressant to work, a psychiatrist should make sure that the diagnosis is correct, that co-morbid psychiatric disorders and medical problems are treated, and that psychosocial issues are addressed adequately.